Serum proteome analysis identifies a potential biomarker for axial psoriatic arthritis.

ABSTRACT:

Background

To identify potential serum biomarkers for differentiating between axial psoriatic arthritis (axPsA) and peripheral psoriatic arthritis (pPsA).

Methods

Serum samples were collected from patients with PsA to create a biomarker discovery cohort and a verification cohort. Patients with PsA were classified into axial or peripheral subtypes based on imaging criteria. Untargeted proteomics technology was used in the discovery phase to screen for biomarkers, and candidate biomarkers were evaluated using enzyme-linked immunosorbent assay (ELISA) in the verification phase.

Results

We identified 45 significantly differentially expressed proteins (DEPs) between axPsA (n = 20) and pPsA (n = 20) with liquid chromatography-mass spectrometry. Among these DEPs, serum pigme

SUBMITTER: Lu C 

PROVIDER: S-EPMC10908212 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature