Immunological signatures unveiled by integrative systems vaccinology characterization of dengue vaccination trials and natural infection.

ABSTRACT:

Introduction

Dengue virus infection is a global health problem lacking specific therapy, requiring an improved understanding of DENV immunity and vaccine responses. Considering the recent emerging of new dengue vaccines, here we performed an integrative systems vaccinology characterization of molecular signatures triggered by the natural DENV infection (NDI) and attenuated dengue virus infection models (DVTs).

Methods and results

We analyzed 955 samples of transcriptomic datasets of patients with NDI and attenuated dengue virus infection trials (DVT1, DVT2, and DVT3) using a systems vaccinology approach. Differential expression analysis identified 237 common differentially expressed genes (DEGs) between DVTs and NDI. Among them, 28 and 60 DEGs were up or downregulated by den

SUBMITTER: Placa DR 

PROVIDER: S-EPMC10912564 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature