Post-infusion CAR T_Reg cells identify patients resistant to CD19-CAR therapy.

ABSTRACT: Approximately 60% of patients with large B cell lymphoma treated with chimeric antigen receptor (CAR) T cell therapies targeting CD19 experience disease progression, and neurotoxicity remains a challenge. Biomarkers associated with resistance and toxicity are limited. In this study, single-cell proteomic profiling of circulating CAR T cells in 32 patients treated with CD19-CAR identified that CD4⁺Helios⁺ CAR T cells on day 7 after infusion are associated with progressive disease and less severe neurotoxicity. Deep profiling demonstrated that this population is non-clonal and manifests hallmark features of T regulatory (T_Reg) cells. Validation cohort analysis upheld the link between higher CAR T_Reg cells with clinical progression and less severe n

SUBMITTER: Good Z 

PROVIDER: S-EPMC10917089 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature