Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias.

ABSTRACT: Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic mutations in MM. Instead, these agents target pathways critical for PC biology yet largely dispensable for malignant or normal cells of most other lineages. Here we systematically characterized the lineage-preferential molecular dependencies of MM through genome-scale clustered regularly interspaced short palindromic repeats (CRISPR) studies in 19 MM versus hundreds of non-MM lines and identified 116 genes whose disruption more significantly affects MM cell fitness compared with other malignancies. These genes, some known, others not previously linked to MM, encode transcription factors,

SUBMITTER: de Matos Simoes R 

PROVIDER: S-EPMC10918623 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature