Association of urine biomarkers of kidney health with subclinical cardiovascular disease among men with and without HIV.

ABSTRACT:

Objective

The aim of this study was to determine whether urine biomarkers of kidney health are associated with subclinical cardiovascular disease among men with and without HIV.

Design

A cross-sectional study within the Multicenter AIDS Cohort Study (MACS) among 504 men with and without HIV infection who underwent cardiac computed tomography scans and had urine biomarkers measured within the preceding 2 years.

Methods

Our primary predictors were four urine biomarkers of endothelial (albuminuria), proximal tubule dysfunction (alpha-1-microglobulin [A1 M] and injury (kidney injury molecule-1 [KIM-1]) and tubulointerstitial fibrosis (pro-collagen-III N-terminal peptide [PIIINP]). These were evaluated for association with coronary artery calcium (CAC) prevalence, CAC exte

SUBMITTER: Lai M 

PROVIDER: S-EPMC10922264 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature