Mecp2 knock-out astrocytes affect synaptogenesis by interleukin 6 dependent mechanisms.

ABSTRACT: Synaptic abnormalities are a hallmark of several neurological diseases, and clarification of the underlying mechanisms represents a crucial step toward the development of therapeutic strategies. Rett syndrome (RTT) is a rare neurodevelopmental disorder, mainly affecting females, caused by mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene, leading to a deep derangement of synaptic connectivity. Although initial studies supported the exclusive involvement of neurons, recent data have highlighted the pivotal contribution of astrocytes in RTT pathogenesis through non-cell autonomous mechanisms. Since astrocytes regulate synapse formation and functionality by releasing multiple molecules, we investigated the influence of soluble factors secreted by Mecp2 knock-ou

SUBMITTER: Albizzati E 

PROVIDER: S-EPMC10926209 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature