Viral Traits and Cellular Knock-Out Genotype Affect Dependence of BVDV on Bovine CD46.
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ABSTRACT:
SUBMITTER: Chen HW
PROVIDER: S-EPMC8704300 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Viral Traits and Cellular Knock-Out Genotype Affect Dependence of BVDV on Bovine CD46.
Chen Hann-Wei HW Huber Verena V Szakmary-Braendle Kati K Seitz Kerstin K Moetz Marlene M Ruemenapf Till T Riedel Christiane C
Pathogens (Basel, Switzerland) 20211214 12
The role of bovine CD46 in the host cell entry of BVDV has been established for more than a decade. By generating novel MDBK CD46 knock-out clones, we confirm previously reported data on the CD46 motives important for BVDV binding and the importance of the G479R exchange within BVDV E<sup>rns</sup> to gain independence of bovine CD46 during entry. The comparison of different knock-out genotypes revealed a high variability of cellular susceptibility for a BVDV encoding the G479R exchange. These d ...[more]
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