Dataset Information

Endoscopic features with linked-color imaging of non-Helicobacter pylori Helicobacter-associated gastritis: a case study.

ABSTRACT:

Background and aims

The endoscopic findings of non-Helicobacter pylori Helicobacter (NHPH) are not widely known. Linked-color imaging (LCI) has emerged as a new system for image-enhanced endoscopy (IEE) that enhances color tone and improves visibility. The aim of this case study was to assess how endoscopic findings of NHPH are enhanced with LCI.

Methods

We report the case of a 72-year-old woman in whom an NHPH species was found during EGD using LCI.

Results

The EGD did not reveal any endoscopic findings of diffuse redness, patchy redness, or atrophy. However, erosions, nonuniform redness, and crack-like mucosa were seen in the antrum, as well as LCI-enhanced endoscopic findings. In addition, nodular gastritis and a white marbled appearance were also observed in the antrum. LCI and blue-laser imaging enhanced the endoscopic findings. Floating bacterial bodies with a fine coil-like shape and diameter longer than that of H pylori were pathologically observed in the mucus, suggesting NHPH. A polymerase chain reaction test led to a diagnosis of Helicobacter suis.

Conclusions

Our case demonstrates that IEE is useful in diagnosing NHPH. The detection of NHPH using IEE enabled us to contribute to an improved diagnosis of NHPH.

SUBMITTER: Takeda T

PROVIDER: S-EPMC10927495 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Publications

Endoscopic features with linked-color imaging of non-<i>Helicobacter pylori</i> Helicobacter-associated gastritis: a case study.

Takeda Tsutomu T Asaoka Daisuke D Hirai Shu S Nakamura Masahiko M Nagahara Akihito A

VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy 20231021 3

<h4>Background and aims</h4>The endoscopic findings of non-<i>Helicobacter pylori</i> Helicobacter (NHPH) are not widely known. Linked-color imaging (LCI) has emerged as a new system for image-enhanced endoscopy (IEE) that enhances color tone and improves visibility. The aim of this case study was to assess how endoscopic findings of NHPH are enhanced with LCI.<h4>Methods</h4>We report the case of a 72-year-old woman in whom an NHPH species was found during EGD using LCI.<h4>Results</h4>The EGD ...[more]

PMID: 38482475

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Project description:BackgroundThere is lack of clinical evidence supporting the value of the Kyoto classification of gastritis for the diagnosis of Helicobacter pylori (H. pylori) infection in Chinese patients, and there aren't enough specific features for the endoscopic diagnosis of past infections, which is of special significance for the prevention of early gastric cancer (GC).MethodsThis was a prospective and multicenter study with 650 Chinese patients. The H. pylori status and gastric mucosal features, including 17 characteristics based on the Kyoto classification and two newly-defined features unclear atrophy boundary (UAB) and RAC reappearance in atrophic mucosa (RAC reappearance) were recorded in a blind fashion. The clinical characteristics of the subjects were analyzed, and the diagnostic odds ratio (DOR), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), area under the receiver operating characteristics curve (ROC/AUC), and 95% confidence intervals were calculated for the different features, individually, and in combination.ResultsFor past infection, the DOR of UAB was 7.69 (95%CI:3.11-19.1), second only to map-like redness (7.78 (95%CI: 3.43-17.7)). RAC reappearance showed the highest ROC/AUC (0.583). In cases in which at least one of these three specific features of past infection was considered positive, the ROC/AUC reached 0.643. For current infection, nodularity showed the highest DOR (11.7 (95%CI: 2.65-51.2)), followed by diffuse redness (10.5 (95%CI: 4.87-22.6)). Mucosal swelling showed the highest ROC/AUC (0.726). Regular arrangement of collecting venules (RAC) was specific for no infection.ConclusionsThis study provides evidence of the clinical accuracy and robustness of the Kyoto classification of gastritis for the diagnosis of H. pylori in Chinese patients, and confirms UAB and RAC reappearance partly supplement it for the diagnosis of past infections, which is of great benefit to the early prevention of GC.