Inflammation-Associated Senescence Promotes Helicobacter pylori-Induced Atrophic Gastritis.

ABSTRACT:

Background & aims

The association between cellular senescence and Helicobacter pylori-induced atrophic gastritis is not clear. Here, we explore the role of cellular senescence in H pylori-induced atrophic gastritis and the underlying mechanism.

Methods

C57BL/6J mice were infected with H pylori for biological and mechanistic studies in vivo. Gastric precancerous lesions from patients and mouse models were collected and analyzed using senescence-associated beta-galactosidase, Sudan Black B, and immunohistochemical staining to analyze senescent cells, signaling pathways, and H pylori infection. Chromatin immunoprecipitation, luciferase reporter assays, and other techniques were used to explore the underlying mechanism in vitro.

Results

Gastric mucosa atrophy was highly a

SUBMITTER: Cai Q 

PROVIDER: S-EPMC7859172 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature