Prediction of kidney failure in children with chronic kidney disease and obstructive uropathy.

ABSTRACT:

Background

Obstructive uropathy (OU) is a leading cause of pediatric kidney injury. Accurate prediction of kidney disease progression may improve clinical outcomes. We aimed to examine discrimination and accuracy of a validated kidney failure risk equation (KFRE), previously developed in adults, in children with OU.

Methods

We identified 118 children with OU and an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m² in the Chronic Kidney Disease in Children study, a national, longitudinal, observational cohort. Each patient's 5-year risk of kidney failure was estimated using baseline data and published parameters for the 4- and 8-variable KFREs. Discriminative ability of the KFRE was estimated using the C statistic for time-to-event analysis. Sensitivi

SUBMITTER: Sebastiao YV 

PROVIDER: S-EPMC10928559 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature