Defining the pharmacokinetic/pharmacodynamic index of piperacillin/tazobactam within a hollow-fibre infection model to determine target attainment in intensive care patients.

ABSTRACT:

Background

It is important to optimize dosing schemes of antibiotics to maximize the probability of therapeutic success. The recommended pharmacokinetic/pharmacodynamic (PK/PD) index for piperacillin/tazobactam therapy in clinical studies ranges widely (50%-100% fT_>1-4×MIC). Dosing schemes failing to achieve PK/PD targets may lead to negative treatment outcomes.

Objectives

The first aim of this study was to define the optimal PK/PD index of piperacillin/tazobactam with a hollow-fibre infection model (HFIM). The second aim was to predict whether these PK/PD targets are currently achieved in critically ill patients through PK/PD model simulation.

Patients and methods

A dose-fractionation study comprising 21 HFIM experiments was performed against a rang

SUBMITTER: Wenker SAM 

PROVIDER: S-EPMC10928666 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature