Dataset Information

Assessing Pharmacokinetic Correlates of Escitalopram-Related Adverse Drug Reactions.

ABSTRACT:

Background

To assess the pharmacokinetic correlates of reported adverse drug reactions (ADRs) under antidepressant treatment with escitalopram (ESC) using a large therapeutic drug monitoring database.

Methods

A large naturalistic sample of inpatients and outpatients prescribed ESC was analyzed. ADRs were classified using the Udvalg for Kliniske Undersogelser side effect rating scale. We compared ESC-treated patients with (n = 35) and without ADRs (n = 273) using ESC plasma concentrations as the primary outcome. We also compared ADR rates in the 2 groups based on 2 cut-off ESC levels reflecting the recommended upper thresholds of the therapeutic reference range of 80 ng/mL, suggested by the consensus therapeutic drug monitoring guidelines, and 40 ng/mL, based on recent meta-analysis data. The effects of age, sex, smoking, daily ESC dose, plasma concentrations, and concentrations corrected for daily dose were included in a binary logistic regression model to predict ADRs.

Results

No differences in clinical, demographic, or pharmacokinetic parameters were observed between patients with and without ADRs (P > 0.05). Patients with ESC-related ADRs were more frequently diagnosed with psychotic disorders than those without (25% vs. 7.1%, P = 0.004). None of the variables was associated with ADR risk. Overall, ADR rates were not significantly different in patients above versus below thresholds of ESC concentrations (ESC concentrations >40 [n = 59] vs. ≤40 ng/mL [n = 249] and >80 [n = 8] vs. ≤80 ng/mL [n = 300]; P = 0.56 and P = 1.0, respectively).

Conclusions

No distinct pharmacokinetic patterns underlying ESC-associated ADRs were observed. Further studies with more specific assessments of ADRs in larger cohorts are required to better identify potential underlying patterns.

SUBMITTER: Kuzin M

PROVIDER: S-EPMC10930353 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Publications

Assessing Pharmacokinetic Correlates of Escitalopram-Related Adverse Drug Reactions.

Kuzin Maxim M Haen Ekkehard E Kuzo Nazar N Endres Katharina K Hiemke Christoph C Paulzen Michael M Schoretsanitis Georgios G

Therapeutic drug monitoring 20240206 2

<h4>Background</h4>To assess the pharmacokinetic correlates of reported adverse drug reactions (ADRs) under antidepressant treatment with escitalopram (ESC) using a large therapeutic drug monitoring database.<h4>Methods</h4>A large naturalistic sample of inpatients and outpatients prescribed ESC was analyzed. ADRs were classified using the Udvalg for Kliniske Undersogelser side effect rating scale. We compared ESC-treated patients with (n = 35) and without ADRs (n = 273) using ESC plasma concent ...[more]

PMID: 38377253

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Dataset Information

Assessing Pharmacokinetic Correlates of Escitalopram-Related Adverse Drug Reactions.

Background

Methods

Results

Conclusions

Publications

Assessing Pharmacokinetic Correlates of Escitalopram-Related Adverse Drug Reactions.

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