Thermodynamic and Structural Study of Budesonide-Exogenous Lung Surfactant System.

ABSTRACT: The clinical benefits of using exogenous pulmonary surfactant (EPS) as a carrier of budesonide (BUD), a non-halogenated corticosteroid with a broad anti-inflammatory effect, have been established. Using various experimental techniques (differential scanning calorimetry DSC, small- and wide- angle X-ray scattering SAXS/WAXS, small- angle neutron scattering SANS, fluorescence spectroscopy, dynamic light scattering DLS, and zeta potential), we investigated the effect of BUD on the thermodynamics and structure of the clinically used EPS, Curosurf^®. We show that BUD facilitates the Curosurf^® phase transition from the gel to the fluid state, resulting in a decrease in the temperature of the main phase transition (Tm) and enthalpy (ΔH). The morphology of the Cu

SUBMITTER: Keshavarzi A 

PROVIDER: S-EPMC10931555 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature