Protective effects of Gα_i3 deficiency in a murine heart-failure model of β₁-adrenoceptor overexpression.

ABSTRACT: We have shown that in murine cardiomyopathy caused by overexpression of the β₁-adrenoceptor, Gα_i2-deficiency is detrimental. Given the growing evidence for isoform-specific Gα_i-functions, we now examined the consequences of Gα_i3 deficiency in the same heart-failure model. Mice overexpressing cardiac β₁-adrenoceptors with (β₁-tg) or without Gα_i3-expression (β₁-tg/Gα_i3^-/-) were compared to C57BL/6 wildtypes and global Gα_i3-knockouts (Gα_i3^-/-). The life span of β₁-tg mice was significantly shortened but improved when Gα_i3 was lacking (95% CI: 592-655 vs. 644-747 days). At 300 days of age, left-ventricular function and survival rat

SUBMITTER: Schroper T 

PROVIDER: S-EPMC10933181 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature