Gα_i3 signaling is associated with sexual dimorphic expression of the clock-controlled output gene Dbp in murine liver.

ABSTRACT: The albumin D-box binding protein (DBP) is a member of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family and functions as important regulator of circadian core and output gene expression. Gene expression of DBP itself is under the control of E-box-dependent binding by the Bmal1-Clock heterodimer and CRE-dependent binding by the cAMP responsive element binding protein (CREB). However, the signaling mechanism mediating CREB-dependent regulation of DBP expression in the peripheral clock remains elusive. In this study, we examined the role of the GPCR (G-protein-coupled receptor)/Gα_i3 (Galphai3) controlled cAMP-CREB signaling pathway in the regulation of hepatic expression of core clock and clock-regulated genes, including Dbp.

SUBMITTER: Singh M 

PROVIDER: S-EPMC6084400 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature