Alzheimer's disease heterogeneity revealed by neuroanatomical normative modeling.

ABSTRACT:

Introduction

Overlooking the heterogeneity in Alzheimer's disease (AD) may lead to diagnostic delays and failures. Neuroanatomical normative modeling captures individual brain variation and may inform our understanding of individual differences in AD-related atrophy.

Methods

We applied neuroanatomical normative modeling to magnetic resonance imaging from a real-world clinical cohort with confirmed AD (n = 86). Regional cortical thickness was compared to a healthy reference cohort (n = 33,072) and the number of outlying regions was summed (total outlier count) and mapped at individual- and group-levels.

Results

The superior temporal sulcus contained the highest proportion of outliers (60%). Elsewhere, overlap between patient atrophy patterns was low. Mean

SUBMITTER: Loreto F 

PROVIDER: S-EPMC10937817 | biostudies-literature | 2024 Jan-Mar

REPOSITORIES: biostudies-literature