Optimal P2Y₁₂ inhibitor durations in older men and older women following an acute myocardial infarction: A nationwide cohort study using Medicare data.

ABSTRACT:

Study objective

Identify optimal P2Y₁₂ inhibitor durations balancing ischemic-benefit and bleeding-risk outcomes after acute myocardial infarction (AMI) in older men and women.

Design

Observational retrospective cohort with 2 years of follow-up, using clone-censor-weight marginal structural models to emulate randomization.

Setting

20 % sample of US Medicare administrative claims data.

Participants

P2Y₁₂ inhibitor new users ≥66 years old following 2008-2013 AMI hospitalization.

Exposures

12- to 24-month P2Y₁₂ inhibitor durations in 1-month intervals.

Main outcome measures

Effectiveness outcome (composite of all-cause mortality, recurrent AMI, ischemic stroke), safety outcome (hospitalized bleed), and negative contro

SUBMITTER: Hickson RP 

PROVIDER: S-EPMC10939016 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature