Sex differences of brain cortical structure in major depressive disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) has different clinical presentations in males and females. However, the neuroanatomical mechanisms underlying these sex differences are not fully understood.

Objective

The purpose of present study was to explore the sex differences in brain cortical thickness (CT) and surface area (SA) of MDD and the relationship between these differences and clinical manifestations in different gender.

Methods

High-resolution T1-weighted images were acquired from 61 patients with MDD and 61 healthy controls (36 females and 25 males, both). The sex differences in CT and SA were obtained using the FreeSurfer software and compared between every two groups by post hoc test. Spearman correlation analysis was also performed to explore the r

SUBMITTER: Mou J 

PROVIDER: S-EPMC10939343 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature