Spatial-temporal order-disorder transition in angiogenic NOTCH signaling controls cell fate specification.

ABSTRACT: Angiogenesis is a morphogenic process resulting in the formation of new blood vessels from pre-existing ones, usually in hypoxic micro-environments. The initial steps of angiogenesis depend on robust differentiation of oligopotent endothelial cells into the Tip and Stalk phenotypic cell fates, controlled by NOTCH-dependent cell-cell communication. The dynamics of spatial patterning of this cell fate specification are only partially understood. Here, by combining a controlled experimental angiogenesis model with mathematical and computational analyses, we find that the regular spatial Tip-Stalk cell patterning can undergo an order-disorder transition at a relatively high input level of a pro-angiogenic factor VEGF. The resulting differentiation is robust but temporally unstable for most cel

SUBMITTER: Kang TY 

PROVIDER: S-EPMC10942579 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature