Anterior cingulate cross-hemispheric inhibition via the claustrum resolves painful sensory conflict.

ABSTRACT: The anterior cingulate cortex (ACC) responds to noxious and innocuous sensory inputs, and integrates them to coordinate appropriate behavioral reactions. However, the role of the projections of ACC neurons to subcortical areas and their influence on sensory processing are not fully investigated. Here, we identified that ACC neurons projecting to the contralateral claustrum (ACC^→contraCLA) preferentially respond to contralateral mechanical sensory stimulation. These sensory responses were enhanced during attending behavior. Optogenetic activation of ACC^→contraCLA neurons silenced pyramidal neurons in the contralateral ACC by recruiting local circuit fast-spiking interneuron activation via an excitatory relay in the CLA. This circuit activation suppressed withdrawal beh

SUBMITTER: Koga K 

PROVIDER: S-EPMC10943010 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature