SIRT3 rs11246020 Polymorphism Associated Postprandial Triglyceride Dysmetabolism.

ABSTRACT:

Purpose

Energy metabolism is regulated by SIRT3, no research has been done on the connection between lipid metabolism in the oral fat test and SIRT3 polymorphism. Thus, we conducted a case-control study to investigate the connection between postprandial lipid and SIRT3 polymorphism.

Patients and methods

402 non-obese Chinese subjects were enrolled and their postprandial lipid response to oral fat tolerance test (OFTT) was observed to understand the relationship between rs11246020 gene and postprandial triglyceride metabolism.

Results

In a binary logic regression model, a protective effect of the T allele of the rs11246020 SIRT3 for postprandial hypertriglyceridemia was shown (OR=0.417, 95% CI = 0.219-0.794, p=0.008). Compared to the CC genotype, individuals with the T

SUBMITTER: Yang L 

PROVIDER: S-EPMC10944304 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature