Dataset Information

An open label feasibility study of a nutrition and exercise app-based solution in cirrhosis.

ABSTRACT:

Background

Nutrition and exercise are the mainstay of therapy for the prevention and treatment of frailty in cirrhosis. This pilot study assessed feasibility of the online delivery of an app-based semi-supervised nutrition and exercise intervention in this population.

Methods

The 11-week pilot recruited adults with cirrhosis who owned internet-connected devices. Patients were encouraged to participate in exercise sessions 3× per week including a combination of online group exercise (weekly) and home-based follow-along exercise (biweekly). They also participated in group nutrition classes (five sessions) and one-to-one exercise and nutrition check-ins delivered through the app. Primary outcome measures pertained to program feasibility: recruitment, retention, adherence, and satisfaction. Exploratory measures included physical performance (liver frailty index [LFI], 6-minute walk test [6MWT]), health behaviour domains, and quality of life.

Results

Twenty three patients completed baseline measures. Of these, 18 (72%) completed end of study measures (mean MELD-Na, 9.2; female, 44.4%). Over 70% of participants fulfilled 75% or more of the feasibility criteria. Satisfaction with the program was high (mean, 89%). Exercise program modifications were required for 17 patients to accommodate health events or abilities. Exploratory evaluation showed improvement in the LFI and the 6MWT by -0.58-units (95% CI: -0.91 to -0.25) and 46.0 m (95% CI: 22.7-69.3) respectively without changes in quality of life or health behaviour domains.

Conclusions

Outcomes demonstrate feasibility of the app-based delivery of programming with promising exploratory impact on efficacy for physical performance. Findings can guide the design of a large-scale app-based randomized controlled trials in cirrhosis.

SUBMITTER: Ismond KP

PROVIDER: S-EPMC10946184 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Publications

An open label feasibility study of a nutrition and exercise app-based solution in cirrhosis.

Ismond Kathleen P KP Cruz Christofer C Limon-Miro Ana Teresa AT Low Gavin G Prado Carla M CM Spence John C JC Raman Maitreyi M McNeely Margaret L ML Tandon Puneeta P

Canadian liver journal 20240226 1

<h4>Background</h4>Nutrition and exercise are the mainstay of therapy for the prevention and treatment of frailty in cirrhosis. This pilot study assessed feasibility of the online delivery of an app-based semi-supervised nutrition and exercise intervention in this population.<h4>Methods</h4>The 11-week pilot recruited adults with cirrhosis who owned internet-connected devices. Patients were encouraged to participate in exercise sessions 3× per week including a combination of online group exercis ...[more]

PMID: 38505789

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Dataset Information

An open label feasibility study of a nutrition and exercise app-based solution in cirrhosis.

Background

Methods

Results

Conclusions

Publications

An open label feasibility study of a nutrition and exercise app-based solution in cirrhosis.

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