Morphological changes of the limbic system associated with acute and chronic low-back pain: A UK biobank imaging study.

ABSTRACT:

Background

Low back pain (LBP) is a major public health issue that influences physical and emotional factors integral to the limbic system. This study aims to investigate the association between LBP and brain morphometry alterations as the duration of LBP increases (acute vs. chronic).

Methods

We used the UK Biobank data to investigate the morphological features of the limbic system in acute LBP (N = 115), chronic LBP (N = 243) and controls (N = 358), and tried to replicate our findings with an independent dataset composed of 45 acute LBP participants evaluated at different timepoints throughout 1 year from the OpenPain database.

Results

We found that in comparison with chronic LBP and pain-free controls, acute LBP was associated with increased volumes of the nucleus

SUBMITTER: Sacca V 

PROVIDER: S-EPMC10947961 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature