Effects of common lifestyle factors on obstructive sleep apnea: precautions in daily life based on causal inferences.

ABSTRACT:

Background

This study aimed to evaluate the causal impact of common modifiable lifestyles on obstructive sleep apnea (OSA), which is beneficial for recommendations to prevent and manage OSA.

Method

Published genome-wide association study (GWAS) summary statistics were used to perform two-sample Mendelian randomization (MR). Variants associated with each exposure of smoking, drinking, and leisure sedentary behaviors at the genetic level were used as instrumental variables (IVs). Then, inverse-variance weighting (IVW) was considered the primary result for causality. Moreover, several complimented approaches were also included to verify the observed associations. MR-PRESSO and MR-Egger intercept were applied to test the horizontal pleiotropy. To assess heterogeneity, Cochran's

SUBMITTER: Liu K 

PROVIDER: S-EPMC10948455 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature