Dataset Information

White and gray matter alterations in bipolar I and bipolar II disorder subtypes compared with healthy controls - exploring associations with disease course and polygenic risk.

ABSTRACT: Patients with bipolar disorder (BD) show alterations in both gray matter volume (GMV) and white matter (WM) integrity compared with healthy controls (HC). However, it remains unclear whether the phenotypically distinct BD subtypes (BD-I and BD-II) also exhibit brain structural differences. This study investigated GMV and WM differences between HC, BD-I, and BD-II, along with clinical and genetic associations. N = 73 BD-I, n = 63 BD-II patients and n = 136 matched HC were included. Using voxel-based morphometry and tract-based spatial statistics, main effects of group in GMV and fractional anisotropy (FA) were analyzed. Associations between clinical and genetic features and GMV or FA were calculated using regression models. For FA but not GMV, we found significant differences between groups. BD-I patients showed lower FA compared with BD-II patients (p_tfce-FWE = 0.006), primarily in the anterior corpus callosum. Compared with HC, BD-I patients exhibited lower FA in widespread clusters (p_tfce-FWE < 0.001), including almost all major projection, association, and commissural fiber tracts. BD-II patients also demonstrated lower FA compared with HC, although less pronounced (p_tfce-FWE = 0.049). The results remained unchanged after controlling for clinical and genetic features, for which no independent associations with FA or GMV emerged. Our findings suggest that, at a neurobiological level, BD subtypes may reflect distinct degrees of disease expression, with increasing WM microstructure disruption from BD-II to BD-I. This differential magnitude of microstructural alterations was not clearly linked to clinical and genetic variables. These findings should be considered when discussing the classification of BD subtypes within the spectrum of affective disorders.

SUBMITTER: Thiel K

PROVIDER: S-EPMC10948847 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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White and gray matter alterations in bipolar I and bipolar II disorder subtypes compared with healthy controls - exploring associations with disease course and polygenic risk.

Thiel Katharina K Lemke Hannah H Winter Alexandra A Flinkenflügel Kira K Waltemate Lena L Bonnekoh Linda L Grotegerd Dominik D Dohm Katharina K Hahn Tim T Förster Katharina K Kanske Philipp P Repple Jonathan J Opel Nils N Redlich Ronny R David Friederike F Forstner Andreas J AJ Stein Frederike F Brosch Katharina K Thomas-Odenthal Florian F Usemann Paula P Teutenberg Lea L Straube Benjamin B Alexander Nina N Jamalabadi Hamidreza H Jansen Andreas A Witt Stephanie H SH Andlauer Till F M TFM Pfennig Andrea A Bauer Michael M Nenadić Igor I Kircher Tilo T Meinert Susanne S Dannlowski Udo U

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20240208 5

Patients with bipolar disorder (BD) show alterations in both gray matter volume (GMV) and white matter (WM) integrity compared with healthy controls (HC). However, it remains unclear whether the phenotypically distinct BD subtypes (BD-I and BD-II) also exhibit brain structural differences. This study investigated GMV and WM differences between HC, BD-I, and BD-II, along with clinical and genetic associations. N = 73 BD-I, n = 63 BD-II patients and n = 136 matched HC were included. Using voxel-ba ...[more]

PMID: 38332015

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Dataset Information

White and gray matter alterations in bipolar I and bipolar II disorder subtypes compared with healthy controls - exploring associations with disease course and polygenic risk.

Publications

White and gray matter alterations in bipolar I and bipolar II disorder subtypes compared with healthy controls - exploring associations with disease course and polygenic risk.

Similar Datasets

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