Ontology highlight
ABSTRACT:
SUBMITTER: Yanovich A
PROVIDER: S-EPMC10949003 | biostudies-literature | 2024
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20240311
A facile approach to novel medicinally relevant spiro heterocyclic scaffolds (namely furan-2(5<i>H</i>)-ones, tetrahydrofurans and pyrans spiro-conjugated with the succinimide ring) has been developed. The protocol consists of Rh(II)-catalyzed insertion of heterocyclic carbenes derived from diazoarylidene succinimides (DAS) into the O-H bond of propiolic/allenic acids or brominated alcohols, followed by base-promoted cyclization to afford the target spirocyclic compounds in good to high yields. ...[more]