Childhood obesity and risk of Alzheimer's disease: a Mendelian randomization study.

ABSTRACT:

Background

Midlife obesity is a modifiable risk factor for Alzheimer's disease. However, the association between childhood obesity and Alzheimer's disease remains largely unknown. Therefore, we conducted a mendelian randomization analysis (MR) to assess the causal link between childhood obesity and Alzheimer's disease.

Methods

Using summary statistics from publicly available genome-wide association studies (GWAS) database, we explored the genetic link between childhood obesity and Alzheimer's disease through a two-sample MR. The primary analysis employed the inverse-variance weighted (IVW) method. To complement our findings, we also employed MR-Egger, weighted median, simple model, and weighted model methods for MR estimates. Furthermore, we conducted Cochrane's Q-statistic

SUBMITTER: Qing W 

PROVIDER: S-EPMC10949616 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature