Dataset Information

Bacillus coagulans TCI711 Supplementation Improved Nonalcoholic Fatty Liver by Modulating Gut Microbiota: A Randomized, Placebo-Controlled, Clinical Trial.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD) has become one of the major problems of chronic liver disease worldwide. It not only causes damage to the liver but also engenders chronic hepatitis and cirrhosis. Recent studies have shown that regulating Bacillus coagulans can improve NAFLD.

Objectives

This trial explores whether B. coagulans TCI711 (BCT) could ameliorate NAFLD.

Methods

A total of 57 patients with NAFLD were recruited through FibroScan liver fibrosis scanner and divided into placebo (n = 28) and BCT-supplemented groups (n = 29). Specifically, 1 BCT probiotic capsule was supplemented daily for 8 wk. Furthermore, the blood, stool, and fatty liver content were then examined.

Results

Parameters evaluated for liver and kidney indicators showed no side effects after supplementing BCT. A significant reduction of 8.7% in the fatty liver was achieved by effectively suppressing the grade of fatty liver as revealed by controlled attenuation parameter. BCT also regulated gut microbiota profiles, with significant increases observed in Bifidobacterium, Eubacterium, Ruminococcaceae, and Sellimonas compared with the baseline.

Conclusions

BCT may improve NAFLD by regulating gut microbiota, and parameters evaluated for liver and kidney indicate no side effects.

SUBMITTER: Hsieh RH

PROVIDER: S-EPMC10951533 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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<i>Bacillus coagulans</i> TCI711 Supplementation Improved Nonalcoholic Fatty Liver by Modulating Gut Microbiota: A Randomized, Placebo-Controlled, Clinical Trial.

Hsieh Rong-Hong RH Chien Yu-Ju YJ Lan Wen-Yi WY Lin Yung-Kai YK Lin Yung-Hsiang YH Chiang Chi-Fu CF Yang Ming-Ta MT

Current developments in nutrition 20240119 3

<h4>Background</h4>Nonalcoholic fatty liver disease (NAFLD) has become one of the major problems of chronic liver disease worldwide. It not only causes damage to the liver but also engenders chronic hepatitis and cirrhosis. Recent studies have shown that regulating <i>Bacillus coagulans</i> can improve NAFLD.<h4>Objectives</h4>This trial explores whether <i>B. coagulans</i> TCI711 (BCT) could ameliorate NAFLD.<h4>Methods</h4>A total of 57 patients with NAFLD were recruited through FibroScan live ...[more]

PMID: 38510931

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