Direct Synthesis of N-formamides by Integrating Reductive Amination of Ketones and Aldehydes with CO₂ Fixation in a Metal-Organic Framework.

ABSTRACT: Formamides are important feedstocks for the manufacture of many fine chemicals. State-of-the-art synthesis of formamides relies on the use of an excess amount of reagents, giving copious waste and thus poor atom-economy. Here, we report the first example of direct synthesis of N-formamides by coupling two challenging reactions, namely reductive amination of carbonyl compounds, particularly biomass-derived aldehydes and ketones, and fixation of CO₂ in the presence of H₂ over a metal-organic framework supported ruthenium catalyst, Ru/MFM-300(Cr). Highly selective production of N-formamides has been observed for a wide range of carbonyl compounds. Synchrotron X-ray powder diffraction reveals the presence of strong host-guest binding interactions via hydrogen bonding and

SUBMITTER: Huang W 

PROVIDER: S-EPMC10952134 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature