Intrinsic and secondary epileptogenicity in focal cortical dysplasia type II.

ABSTRACT:

Objective

Favorable seizure outcome is reported following resection of bottom-of-sulcus dysplasia (BOSD). We assessed the distribution of epileptogenicity and dysplasia in and around BOSD to better understand this clinical outcome and the optimal surgical approach.

Methods

We studied 27 children and adolescents with magnetic resonance imaging (MRI)-positive BOSD who underwent epilepsy surgery; 85% became seizure-free postresection (median = 5.0 years follow-up). All patients had resection of the dysplastic sulcus, and 11 had additional resection of the gyral crown (GC) or adjacent gyri (AG). Markers of epileptogenicity were relative cortical hypometabolism on preoperative ¹⁸ F-fluorodeoxyglucose (FDG) positron emission tomography (PET), and spiking, ripples, fast

SUBMITTER: Macdonald-Laurs E 

PROVIDER: S-EPMC10952144 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature