IĸB Protein BCL3 as a Controller of Osteogenesis and Bone Health.

ABSTRACT:

Objective

IĸB protein B cell lymphoma 3-encoded protein (BCL3) is a regulator of the NF-κB family of transcription factors. NF-κB signaling fundamentally influences the fate of bone-forming osteoblasts and bone-resorbing osteoclasts, but the role of BCL3 in bone biology has not been investigated. The objective of this study was to evaluate BCL3 in skeletal development, maintenance, and osteoarthritic pathology.

Methods

To assess the contribution of BCL3 to skeletal homeostasis, neonatal mice (n = 6-14) lacking BCL3 (Bcl3^-/- ) and wild-type (WT) controls were characterized for bone phenotype and density. To reveal the contribution to bone phenotype by the osteoblast compartment in Bcl3^-/- mice, transcriptomic analysis of early osteogenic differentiation

SUBMITTER: Jaffery H 

PROVIDER: S-EPMC10952620 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature