Inhibition of oxidative stress by apocynin attenuated chronic obstructive pulmonary disease progression and vascular injury by cigarette smoke exposure.

ABSTRACT:

Background and purpose

Cardiovascular disease affects up to half of the patients with chronic obstructive pulmonary disease (COPD), exerting deleterious impact on health outcomes and survivability. Vascular endothelial dysfunction marks the onset of cardiovascular disease. The present study examined the effect of a potent NADPH Oxidase (NOX) inhibitor and free-radical scavenger, apocynin, on COPD-related cardiovascular disease.

Experimental approach

Male BALB/c mice were exposed to either room air (Sham) or cigarette smoke (CS) generated from 9 cigarettes·day^-1 , 5 days a week for up to 24 weeks with or without apocynin treatment (5 mg·kg^-1 ·day^-1 , intraperitoneal injection).

Key results

Eight-weeks of apocynin treatment reduced airwa

SUBMITTER: Chan SMH 

PROVIDER: S-EPMC10953324 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature