Dataset Information

The association between long-term exposure to ambient PM_2.5 and high-density lipoprotein cholesterol level among chinese middle-aged and older adults.

ABSTRACT:

Background

Recently, the impact of PM_2.5 on human health has been intensively studied, especially the respiratory system. High-density lipoprotein plays a crucial role in removing excess cholesterol from cells and transporting it to the liver for excretion. However, the effects of ambient PM2.5 on high-density lipoprotein (HDL) level have not been further studied. Our research aims to investigate the potential association between ambient PM_2.5 concentrations and high-density lipoprotein (HDL) levels within the middle-aged and older adults in China.

Methods

We employed data from individuals aged 45 years and above who were participants in Wave 3 of the China Health and Retirement Longitudinal Study (CHARLS). The high-quality, high-resolution PM_2.5 exposure concentration data for each participant were obtained from the ChinaHighAirPollutants (CHAP) dataset, while the HDL levels were derived from blood samples collected during CHARLS Wave 3. This analysis constitutes a cross-sectional study involving a total of 12,519 participants. To investigate associations, we conducted multivariate linear regression analysis, supplemented by subgroup analysis.

Results

In this cross-sectional investigation, we discerned a negative association between prolonged exposure to ambient PM_2.5 constituents and high-density lipoprotein (HDL) levels. The observed correlation between ambient PM_2.5 and HDL levels suggests that older individuals residing in areas with elevated PM_2.5 concentrations exhibit a reduction in HDL levels (Beta: -0.045; 95% CI: -0.056, -0.035; P < 0.001). Upon adjusting for age in Model I, the Beta coefficient remained consistent at -0.046 (95% CI: -0.056, -0.035; p < 0.001). This association persisted even after accounting for various potential confounding factors (Beta = -0.031, 95% CI: -0.041, -0.021, p < 0.001).

Conclusions

Our study reveals a statistically significant negative correlation between sustained exposure to higher concentrations of ambient PM_2.5 and high-density lipoprotein (HDL) levels among Chinese middle-aged and older individuals.

SUBMITTER: Liu C

PROVIDER: S-EPMC10956307 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

The association between long-term exposure to ambient PM<sub>2.5</sub> and high-density lipoprotein cholesterol level among chinese middle-aged and older adults.

Liu Chaolin C Qiao Yong Y

BMC cardiovascular disorders 20240321 1

<h4>Background</h4>Recently, the impact of PM<sub>2.5</sub> on human health has been intensively studied, especially the respiratory system. High-density lipoprotein plays a crucial role in removing excess cholesterol from cells and transporting it to the liver for excretion. However, the effects of ambient PM2.5 on high-density lipoprotein (HDL) level have not been further studied. Our research aims to investigate the potential association between ambient PM<sub>2.5</sub> concentrations and hig ...[more]

PMID: 38515043

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Project description:BackgroundThe ratio of non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) (NHHR) served as a novel comprehensive lipid indicator. This study aimed to explore the association between NHHR and the incidence of cardiometabolic multimorbidity (CMM).MethodsThis study included 8191 individuals from the China Health and Retirement Longitudinal Study (CHARLS) database. We used multivariable cox proportional hazards regression, logistic regression, and restricted cubic splines (RCS) analysis to evaluate the association between NHHR and CMM. Subgroup analyses and interaction tests were also performed.ResultsThe incidences of CMM among participants in quartiles (Q) 1-4 of NHHR were 7.03%, 8.3%, 10.06%, and 16.55%, respectively. The NHHR was significantly higher in individuals with CMM compared to those without CMM (P < 0.001). When assessed as a continuous variable, NHHR was independently associated with the risk of CMM, as demonstrated by both multivariable cox proportional hazards regression analysis (HR = 1.05, 95% CI = 1.02-1.07, P < 0.001) and logistic regression analysis (OR = 1.09, 95% CI = 1.04-1.15, P < 0.001). Compared to individuals in the lowest quartiles of the NHHR (Q1), the risk of CMM in the highest quartiles (Q4) was increased by 1.25-fold according to multivariable cox proportional hazards regression analysis (HR = 2.25, 95% CI = 1.73-2.93, P < 0.001) and by 1.48-fold according to logistic regression analysis (OR = 2.48, 95% CI = 1.86-3.31, P < 0.001). This association was consistent across nearly all subgroups. RCS analysis revealed a significant nonlinear association between NHHR and CMM. Additionally, the predictive ability of NHHR for CMM was 0.613, which was superior to that of both HDL-C and non-HDL-C (P < 0.05). Furthermore, the composite variable comprising NHHR and other traditional risk factors exhibited the highest predictive value (C statistic = 0.679).ConclusionA higher NHHR was closely associated with an increased risk of CMM. Further studies on NHHR could be beneficial for preventing and treating CMM.

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Dataset Information

The association between long-term exposure to ambient PM_2.5 and high-density lipoprotein cholesterol level among chinese middle-aged and older adults.

Background

Methods

Results

Conclusions

Publications

The association between long-term exposure to ambient PM<sub>2.5</sub> and high-density lipoprotein cholesterol level among chinese middle-aged and older adults.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

The association between long-term exposure to ambient PM2.5 and high-density lipoprotein cholesterol level among chinese middle-aged and older adults.

Background

Methods

Results

Conclusions

Publications

The association between long-term exposure to ambient PM<sub>2.5</sub> and high-density lipoprotein cholesterol level among chinese middle-aged and older adults.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

The association between long-term exposure to ambient PM_2.5 and high-density lipoprotein cholesterol level among chinese middle-aged and older adults.