T- and L-Type Calcium Channels Maintain Calcium Oscillations in the Murine Zona Glomerulosa.

ABSTRACT:

Background

The zona glomerulosa of the adrenal gland is responsible for the synthesis and release of the mineralocorticoid aldosterone. This steroid hormone regulates salt reabsorption in the kidney and blood pressure. The most important stimuli of aldosterone synthesis are the serum concentrations of angiotensin II and potassium. In response to these stimuli, voltage and intracellular calcium levels in the zona glomerulosa oscillate, providing the signal for aldosterone synthesis. It was proposed that the voltage-gated T-type calcium channel Ca_V3.2 is necessary for the generation of these oscillations. However, Cacna1h knock-out mice have normal plasma aldosterone levels, suggesting additional calcium entry pathways.

Methods

We used a combination of calciu

SUBMITTER: Dinh HA 

PROVIDER: S-EPMC10956685 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature