Profiling of immune infiltration landscape of ruptured intracranial aneurysm.

ABSTRACT:

Background

Previous research has indicated that the rupture of intracranial aneurysm (IA) is a significant contributor to mortality from stroke. The objective of this present study was to examine the infiltration patterns in ruptured intracranial aneurysm (RIA), with the aim of generating insights that could inform the development of effective immunotherapeutic approaches.

Methods

To achieve this, we obtained Gene Expression Omnibus datasets pertaining to ruptured aneurysms, encompassing a total of 19 unruptured intracranial aneurysms (UIA) and 27 RIA. Subsequently, we conducted differential gene analysis and immune cell analysis specifically for the RIA.

Results

According to the conducted studies, the analysis has identified 10 hub genes within key modules. Through t

SUBMITTER: Li C 

PROVIDER: S-EPMC10957028 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature