Examining the relationship between genetic risk for depression and youth episodic stress exposure.

ABSTRACT:

Background

Offspring of depressed mothers have elevated risk of developing depression because they are exposed to greater stress. While generally assumed that youth's increased exposure to stress is due to the environmental effects of living with a depressed parent, youth's genes may influence stress exposure through gene-environment correlations (rGEs). To understand the relationship between risk for depression and stress, we examined the effects of polygenic risk for depression on youth stress exposure.

Methods

We examined the relations of a polygenic risk score (PRS) for depression (DEP-PRS), as well as PRSs for 5 other disorders, with youth stress exposure. Data were from a longitudinal study of a community sample of youth and their parents (n = 377) focusing on data col

SUBMITTER: Harrison TJ 

PROVIDER: S-EPMC10958668 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature