Overlap Syndrome of Diffuse Systemic Sclerosis, Sjogren Syndrome, and ANCA-Associated Renal-Limited Vasculitis: Three Entities in One Patient – Case Report
Project description:Systemic sclerosis (SSc) is a rare but devastating disease of fibrosis impacting the dermis and multiple organ systems. The prevalence ranges from 4 to 489 cases per million individuals with ten year mortality rates reported around 18 percent. Survival is related to the extent of skin involvement, yet the precise mechanisms driving skin fibrosis in SSc remain unknown. In this study, we analyzed the shared and unique transcriptomic profiles of SSc and normal keratinocytes.