Omentin-1 inhibits the development of benign prostatic hyperplasia by attenuating local inflammation.

ABSTRACT:

Background

Benign prostatic hyperplasia (BPH) is a prevalent disease affecting elderly men, with chronic inflammation being a critical factor in its development. Omentin-1, also known as intelectin-1 (ITLN-1), is an anti-inflammatory protein primarily found in the epithelial cells of the small intestine. This study aimed to investigate the potential of ITLN-1 in mitigating BPH by modulating local inflammation in the prostate gland.

Methods

Our investigation involved two in vivo experimental models. Firstly, ITLN-1 knockout mice (Itln-1^-/-) were used to study the absence of ITLN-1 in BPH development. Secondly, a testosterone propionate (TP)-induced BPH mouse model was treated with an ITLN-1 overexpressing adenovirus. We assessed BPH severity using prostate weight i

SUBMITTER: Wang YY 

PROVIDER: S-EPMC10960431 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature