Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health.

ABSTRACT:

Background

Epigenetic Scores (EpiScores) for blood protein levels have been associated with disease outcomes and measures of brain health, highlighting their potential usefulness as clinical biomarkers. They are typically derived via penalised regression, whereby a linear weighted sum of DNA methylation (DNAm) levels at CpG sites are predictive of protein levels. Here, we examine 84 previously published protein EpiScores as possible biomarkers of cross-sectional and longitudinal measures of general cognitive function and brain health, and incident dementia across three independent cohorts.

Results

Using 84 protein EpiScores as candidate biomarkers, associations with general cognitive function (both cross-sectionally and longitudinally) were tested in three independent cohort

SUBMITTER: Smith HM 

PROVIDER: S-EPMC10962132 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature