Cortical lipid metabolic pathway alteration of early Alzheimer's disease and candidate drugs screen.

ABSTRACT:

Background

Lipid metabolism changes occur in early Alzheimer's disease (AD) patients. Yet little is known about metabolic gene changes in early AD cortex.

Methods

The lipid metabolic genes selected from two datasets (GSE39420 and GSE118553) were analyzed with enrichment analysis. Protein-protein interaction network construction and correlation analyses were used to screen core genes. Literature analysis and molecular docking were applied to explore potential therapeutic drugs.

Results

60 lipid metabolic genes differentially expressed in early AD patients' cortex were screened. Bioinformatics analyses revealed that up-regulated genes were mainly focused on mitochondrial fatty acid oxidation and mediating the activation of long-chain fatty acids, phosphoproteins, and ch

SUBMITTER: Wang L 

PROVIDER: S-EPMC10962147 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature