Microbiological Methods Used in the Enterics for Global Health Shigella Surveillance Study.

ABSTRACT:

Background

Shigella is a major cause of diarrhea in young children worldwide. Multiple vaccines targeting Shigella are in development, and phase 3 clinical trials are imminent to determine efficacy against shigellosis.

Methods

The Enterics for Global Health (EFGH) Shigella surveillance study is designed to determine the incidence of medically attended shigellosis in 6- to 35-month-old children in 7 resource-limited settings. Here, we describe the microbiological methods used to isolate and identify Shigella. We developed a standardized laboratory protocol for isolation and identification of Shigella by culture. This protocol was implemented across all 7 sites, ensuring consistency and comparability of results. Secondary objectives of the st

SUBMITTER: Horne B 

PROVIDER: S-EPMC10962722 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature