Molecular basis underlying changes of brain entropy and functional connectivity in major depressive disorders after electroconvulsive therapy.

ABSTRACT:

Introduction

Electroconvulsive therapy (ECT) is widely used for treatment-resistant depression. However, it is unclear whether/how ECT can be targeted to affect brain regions and circuits in the brain to dynamically regulate mood and cognition.

Methods

This study used brain entropy (BEN) to measure the irregular levels of brain systems in 46 major depressive disorder (MDD) patients before and after ECT treatment. Functional connectivity (FC) was further adopted to reveal changes of functional couplings. Moreover, transcriptomic and neurotransmitter receptor data were used to reveal genetic and molecular basis of the changes of BEN and functional connectivities.

Results

Compared to pretreatment, the BEN in the posterior cerebellar lobe (PCL) significantly decreased and

SUBMITTER: Yu X 

PROVIDER: S-EPMC10964037 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature