OCTN2- and ATB^0,+-targeted nanoemulsions for improving ocular drug delivery.

ABSTRACT: Traditional eye drops are administered via topical instillation. However, frequent dosing is needed due to their relatively rapid precorneal removal and low ocular bioavailability. To address these issues, stearoyl L-carnitine-modified nanoemulsions (SC-NEs) were fabricated. The physicochemical properties of SC-NEs in terms of size, morphology, zeta potential, encapsulation efficiency, and in vitro drug release behavior were characterized. The cellular uptake and mechanisms of SC-NEs were comprehensively studied in human corneal epithelial cells and the stearoyl L-carnitine ratio in SC-NEs was optimized. The optimized SC-NEs could target the novel organic cation/carnitine transporter 2 (OCTN2) and amino acid transporter B (0 +) (ATB^0,+) on the corneal epithelium, which led to su

SUBMITTER: Tang B 

PROVIDER: S-EPMC10964573 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature