Deficiency of mastl, a mitotic regulator, results in cell detachment from developing tissues of zebrafish embryos.

ABSTRACT: To form tissues with unique functions and structures, it is important that the cells that comprise them maintain physical contact. On the other hand, with each mitosis, drastic changes in cell shapes, cell adhesion, and cytoskeletal architecture may cause such contacts to be temporarily weakened, risking improper development and maintenance of tissues. Despite such risks, tissues form properly during normal development. However, it is not well understood whether mitotic abnormalities affect tissue formation. Here, analysis of zebrafish embryos with aberrant mitosis shows that proper progression of mitosis is important to maintain cell contact in developing tissues. By screening mutants with abnormal trunk and tail development, we obtained a mutant with perturbed expression of some tissue-s

SUBMITTER: Utsumi H 

PROVIDER: S-EPMC10964716 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature