Kidney and heart failure events are bidirectionally associated in patients with type 2 diabetes and cardiovascular disease.

ABSTRACT:

Aims

This study aimed to evaluate the bidirectional relationship between kidney and cardiovascular (CV) events in trial participants with type 2 diabetes and CV disease.

Methods and results

Post hoc analyses of EMPA-REG OUTCOME using Cox regression models were performed to assess the association of baseline factors with risk of a kidney event and bidirectional associations of incident kidney events and CV events. Among placebo-treated participants, baseline factors significantly associated with greater kidney event risk included lower baseline estimated glomerular filtration rate, albuminuria, higher uric acid, low-density lipoprotein cholesterol levels, and prior heart failure (HF). Coronary artery disease was not associated with increased risk. In placebo-treated participa

SUBMITTER: Sharma A 

PROVIDER: S-EPMC10966270 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature