Heterogeneous subpopulations of GABA_AR-responding neurons coexist across neuronal network scales and developmental stages in health and disease.

ABSTRACT: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in adults. Depolarizing GABA responses have been well characterized at neuronal-population average level during typical neurodevelopment and partially in brain disorders. However, no investigation has specifically assessed whether a mosaicism of cells with either depolarizing or hyperpolarizing/inhibitory GABAergic responses exists in animals in health/disease at diverse developmental stages, including adulthood. Here, we showed that such mosaicism is present in wild-type (WT) and down syndrome (DS) neuronal networks, as assessed at increasing scales of complexity (cultures, brain slices, behaving mice). Nevertheless, WT mice presented a much lower percentage of cells with depolarizing GABA than DS mice. R

SUBMITTER: Colombi I 

PROVIDER: S-EPMC10966311 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature