Serum phosphate is associated with increased risk of bone fragility fractures in haemodialysis patients.

ABSTRACT:

Background

Bone fragility fractures are associated with high morbidity and mortality. This study analysed the association between the current biochemical parameters of chronic kidney disease-mineral and bone disorders (CKD-MBD) and bone fragility fractures in the COSMOS (Current management Of Secondary hyperparathyroidism: a Multicentre Observational Study) project.

Methods

COSMOS is a 3-year, multicentre, open cohort, prospective, observational study carried out in 6797 haemodialysis patients (227 centres from 20 European countries). The association of bone fragility fractures (outcome) with serum calcium, phosphate and parathyroid hormone (PTH) (exposure), was assessed using standard Cox proportional hazards regression and Cox proportional hazards regression for recurrent

SUBMITTER: Barrera-Baena P 

PROVIDER: S-EPMC10966329 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature