Dataset Information

Impact of Intracranial Volume and Brain Volume on the Prognostic Value of Computed Tomography Perfusion Core Volume in Acute Ischemic Stroke.

ABSTRACT:

Background

Computed tomography perfusion (CTP)-estimated core volume is associated with functional outcomes in acute ischemic stroke. This relationship might differ among patients, depending on brain volume.

Materials and methods

We retrospectively included patients from the MR CLEAN Registry. Cerebrospinal fluid (CSF) and intracranial volume (ICV) were automatically segmented on NCCT. We defined the proportion of the ICV and total brain volume (TBV) affected by the ischemic core as ICV_core and TBV_core. Associations between the core volume, ICV_core, TBV_core, and functional outcome are reported per interquartile range (IQR). We calculated the area under the curve (AUC) to assess diagnostic accuracy.

Results

In 200 patients, the median core volume was 13 (5-41) mL. Median ICV and TBV were 1377 (1283-1456) mL and 1108 (1020-1197) mL. Median ICV_core and TBV_core were 0.9 (0.4-2.8)% and 1.7 (0.5-3.6)%. Core volume (acOR per IQR 0.48 [95%CI 0.33-0.69]), ICV_core (acOR per IQR 0.50 [95%CI 0.35-0.69]), and TBV_core (acOR per IQR 0.41 95%CI 0.33-0.67]) showed a lower likelihood of achieving improved functional outcomes after 90 days. The AUC was 0.80 for the prediction of functional independence at 90 days for the CTP-estimated core volume, the ICV_core, and the TBV_core.

Conclusion

Correcting the CTP-estimated core volume for the intracranial or total brain volume did not improve the association with functional outcomes in patients who underwent EVT.

SUBMITTER: Hoving JW

PROVIDER: S-EPMC10971384 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Publications

Impact of Intracranial Volume and Brain Volume on the Prognostic Value of Computed Tomography Perfusion Core Volume in Acute Ischemic Stroke.

Hoving Jan W JW Konduri Praneeta R PR Tolhuisen Manon L ML Koopman Miou S MS van Voorst Henk H Van Poppel Laura M LM Daems Jasper D JD van Es Adriaan C G M ACGM van Walderveen Marianne A A MAA Lingsma Hester F HF Dippel Diederik W J DWJ Van Zwam Wim H WH Marquering Henk A HA Majoie Charles B L M CBLM Emmer Bart J BJ

Journal of cardiovascular development and disease 20240228 3

<h4>Background</h4>Computed tomography perfusion (CTP)-estimated core volume is associated with functional outcomes in acute ischemic stroke. This relationship might differ among patients, depending on brain volume.<h4>Materials and methods</h4>We retrospectively included patients from the MR CLEAN Registry. Cerebrospinal fluid (CSF) and intracranial volume (ICV) were automatically segmented on NCCT. We defined the proportion of the ICV and total brain volume (TBV) affected by the ischemic core ...[more]

PMID: 38535103

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Dataset Information

Impact of Intracranial Volume and Brain Volume on the Prognostic Value of Computed Tomography Perfusion Core Volume in Acute Ischemic Stroke.

Background

Materials and methods

Results

Conclusion

Publications

Impact of Intracranial Volume and Brain Volume on the Prognostic Value of Computed Tomography Perfusion Core Volume in Acute Ischemic Stroke.

Similar Datasets

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