Coronary atheroma burden predicts flow reserve in women with ischemia and nonobstructive coronary artery disease.

ABSTRACT:

Background

Women with signs and symptoms of ischemia and no obstructive coronary artery disease often have coronary microvascular dysfunction (CMD) with reduced coronary flow reserve (CFR), and compensatory coronary remodeling. Angiographic measurements of epicardial coronary anatomy (AMCA) may improve understanding of relations between CFR and atherosclerosis. We investigated AMCA and CFR in women evaluated for CMD.

Methods

Women consecutively enrolled in the Women's Ischemia Syndrome Evaluation CVD Continuation (NCT00832702) were included. All underwent clinically indicated coronary function testing measuring CFR. AMCA included coronary angiographic atheroma burden (AB), percent diameter stenosis (PDS), and tapering reference diameter Z score (RDZ), derived for the left ma

SUBMITTER: Pacheco C 

PROVIDER: S-EPMC10976284 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature