AC024896.1/miR-363-3p Axis Regulates the Malignant Progression of Acute Myeloid Leukemia by Cuproptosis-Related Gene MYO1B.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is a hematological malignancy with poor patient prognosis. Cuprotosis is a newly discovered cell death that regulates the proliferation and progression of tumor cells. Long non-coding RNAs (lncRNAs) are key molecules and potential biomarkers for the diagnosis and treatment of various diseases. However, the effect of cuprotosis-associated lncRNAs on AML remains unclear.

Objective

The aim of this study was to investigate the relationship between the expression of cuprotosis-related gene and the prognosis of AML.

Methods

Consensus cluster analysis was performed on AML patients according to the cuprotosis-related gene expression matrix, and survival analysis and differential gene analysis were performed. Then lncRNA and miRNA relate

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10976969 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature